How do stem cells and other progenitor cells determine how to respond to physical cues in specialized, site-appropriate ways? When is this necessary for homeostasis? The Doyle group studies how stem cells learn to respond to mechanical forces and electrical cues during the development and maintenance of the nervous and cardiovascular organ systems. We use approaches from biology, engineering, and computer science to study the molecular circuits that enable specialized mechanosignaling. We seek quantitative insights to help design cell and regenerative medicine therapies for neural and vascular applications.